The Premier League says its clubs have “reluctantly but unanimously” decided not to release players for matches in red-list countries during September’s international break.
Under current UK government rules, players would be forced to miss several games because of the 10-day isolation period required on return to the UK.
The Premier League said “extensive talks” had taken place with the Football Association and government “to find a solution” but that “no exemption had been granted”.
It added that it “strongly supported” the move made by top-flight sides, which “will apply to nearly 60 players from 19 clubs who are due to travel to 26 red-list countries”.