Two-time Wimbledon champion Andy Murray joined Emma Raducanu through the exit door after a four-set defeat by John Isner.
Big-serving American Isner secured a first career victory over the Scot at the ninth attempt, firing down 36 aces in a 6-4 7-6 (7-4) 6-7 (3-7) 6-4 win.
The Scot managed to win only 15 points against the relentless Isner first serve.
But there was so much more to the 20th seed’s victory, with a host of neat drop shots and deft touches at the net leaving Centre Court stunned.
